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  • 2018-02-07 (xsd:date)
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  • Does Zantac Cause False Positives for Methamphetamines? (en)
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  • In 2016, a claim that use of the over-the-counter acid reflux medication Zantac (ranitidine) had produced a false positive result for methamphetamines appeared on social media; that claim resurfaced again in 2018. While the claim piqued the interest social media, it was not new: The prospect of a false positive for amphetamines due to Zantac has been discussed since the late 1980s, when a specific laboratory test for amphetamines produced by a company called Syva (now part of the German conglomerate Siemens AG) was introduced into the market. This test, named the monoclonal EMIT® d.a.u assay, was shown to have produced a single false positive in a brief 1989 report. As a followup to this report, researchers conducted a somewhat larger-scale study in 1991 to investigate the possibility of false positives. They concluded that, while possible, it required extremely specific circumstance: These examples are, essentially, moot, as the Syva monoclonal EMIT® d.a.u assay has been replaced by newer technology that does not suffer from his problem. Still, the issue of possible Zantac/amphetamine false positives has been raised for another test — the the Beckman Coulter Synchron AMPH — as recently as 2015. A report from the University of Pittsburgh School of Medicine concluded: The possible mechanism for false positives, in both cases, is not the chemical similarity of Zantac to amphetamines, but through the presence of unintended reactions between Zantac and the chemicals meant to interact with amphetamines, a problem known as cross-reactivity, which is described in a 2004 review on the topic: With this information in mind, we rate the claim that Zantac causes false positives for methamphetamine a mixture because, while there remains a possibility that at least one test on the market could conceivably produce a false positive for amphetamines from Zantac, the conditions that require such a result are rare and most tests do not suffer from this potential problem. Additionally, the test that generated the most attention in terms of potential false positives is no longer in regular use. (en)
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